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          Synthesis of cluster mannosides via a Ugi four-component reaction and their inhibition against the binding of yeast mannan to concanavalin A

          管華詩 , Yingxia Li , * Xiaoru Zhang , Shidong Chu , Kunyu Yu and Huashi Guan

          Carbohydrate Research 339(2004)873-879,-0001,():

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          摘要/描述

          The Ugifour-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides with different scaolds. The glycoclusters obtained were tested for their relative inhibitory potency against the binding of yeast mannan to concanavalin A by solid-phase enzyme-linked lectin assays (ELLA) using methyl a-D-mannopyranoside as a standard. Among them, a divalent mannoside containing aromatic groups showed the strongest binding a?nity to concanavalin A.

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